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The liver produces high levels of thiomethyl metabolites from glutathione conjugates We then used in vitro liver models (HepaRG-HRG-and primary human hepatocytes-PHH) to provide a better understanding of the formation of these thiomethyl metabolites (in particular to identify their precursors), and a better understanding of the site where the biotransformation occurs
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Blood 112 , 3474–3483 (2008)
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